Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas. Further molecular analysis indicated that the CpG islands play a role in the promoter activity of the TFF1 gene. The expression of TFF1 and DNA methylation of its promoter affected cell proliferation and apoptosis. The expression of TFF1 in gastric cell lines was restored with a demethylating agent, 5‑azacytidine. Low expression of TFF1 in gastric cell lines and cancer tissue is associated with TP Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene (also called pS2 gene. Function. Members of the trefoil family are characterized by having at least one copy of Aliases: TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2, trefoil factor 1.
Tff1 gene cards chop
Dec 06, · TFF1 trefoil factor 1 [ (human)] Gene ID: , updated on 6-Dec Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in . Mice homozygous for a knockout allele exhibit small intestine and gastric mucosa abnormalities and develop antropyloric adenomas with full penetrance; one-third of homozygotes develop multifocal intraepithelial or intramucosal carcinomas. This page is an index of all of the genes currently available in the GeneCards Database. Clicking on one of the links below will bring you to a page that lists all of the genes that begin with that letter or number. For instance, if you click on A, you will get a list of all genes . Free for academic non-profit institutions. Other users need a Commercial license. Keywords. Keywords; Symbols; Symbols/Aliases; Symbols/Aliases/Identifiers. A subset of breast tumors also highly expresses TOX3, with poor outcome associated with high expression of TOX3 in luminal B breast cancers. We also demonstrate the ability of TOX3 to alter gene expression in MCF7 luminal breast cancer cells, including cancer relevant genes TFF1 and CXCR4.Complete information for TTF1 gene (Protein Coding), Transcription Termination This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also .. C/EBPalpha; Cart-1; CHOP; FOXJ2; FOXJ2 (long isoform); GATA Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5. orthologs, and expression. GeneCards - The Human Gene Compendium. have been observed for this gene. This gene shares the symbol/alias 'TFF1'. GeneCards - The Human Gene Compendium. CHOP10; CHOP; DDIT3 Upstream Open Reading Frame Protein; DNA-Damage-Inducible Transcript 3. As with other oncogenes, genetic recombination with the viral genome led to their Effect of Helicobacter pylori Infection on GATA-5 and TFF1 Regulation.
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Gene Music using Protein Sequence of TFF1 "TREFOIL FACTOR 1", time: 1:26
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